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Anand Agricultural University, Anand

Anand Agricultural University (AAU) was established in 2004 at Anand with the support of the Government of Gujarat, Act No.(Guj 5 of 2004) dated April 29, 2004. Caved out of the erstwhile Gujarat Agricultural University (GAU), the dream institution of Sardar Vallabhbhai Patel and Dr. K. M. Munshi, the AAU was set up to provide support to the farming community in three facets namely education, research and extension activities in Agriculture, Horticulture Engineering, product Processing and Home Science. At present there seven Colleges, seventeen Research Centers and six Extension Education Institute working in nine districts of Gujarat namely Ahmedabad, Anand, Dahod, Kheda, Panchmahal, Vadodara, Mahisagar, Botad and Chhotaudepur AAU's activities have expanded to span newer commodity sectors such as soil health card, bio-diesel, medicinal plants apart from the mandatory ones like rice, maize, tobacco, vegetable crops, fruit crops, forage crops, animal breeding, nutrition and dairy products etc. the core of AAU's operating philosophy however, continues to create the partnership between the rural people and committed academic as the basic for sustainable rural development. In pursuing its various programmes AAU's overall mission is to promote sustainable growth and economic independence in rural society. AAU aims to do this through education, research and extension education. Thus, AAU works towards the empowerment of the farmers.

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Subject: Veterinary Surgery and Radiology × End date: 2009 × Start date: 2000 × Type: Thesis × Thesis Type: Ph.D ×
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    ThesisItemOpen Access
    STUDIES ON DRUG ELUTING STENTS IN PREVENTION OF RENAL ARTERY STENOSIS IN DOGS
    (AAU, Anand, 2007) Shivaji Harischandra Talekar; Dr. D. B. PATIL
    In the human interventional endovascular therapy, late stent thrombosis and in-stent restenosis (ISR) have emerged, as a major safety concern with use of drug eluting stents. Late stent thrombosis is associated with high mortality and morbidity. To enhance thrombo-resistance and reduce the dependence on long term dual antiplatelet therapy, use of biodegradable polymer stent platform and heparin along with sirolimus is one approach. Hence a Heparin-Sirolimus (HS) eluting stent (HSES) using biodegradable platform in an evolved in vivo dog’s balloon injured renal artery model for in-stent restenosis was evaluated for effects of dual drug elution on peristrut fibrin deposition and re-endotheliazation. Six HSESs were compared with 6 Sirolimus eluting stents (SESs; control) by implantation into right balloon injured renal arteries of 12 healthy mongrel dogs. With Acepromazine-Diazepam-Ketamine anaesthesia, under fluoroscopic guidance of image intensifier television using 3mm coronary balloon catheter, Synchronium (HSES) and Supralimus (SES) stents (3 mm diameter and 11 mm long) were deployed. Stents were successfully deployed at 6 atm balloon dilation pressure in prior balloon injured renal polar arteries at 8 atm for 60 seconds. Animals of both [(HS (n=6) and SRL (n=6)] groups received no anticoagulation therapy. Peristrut fibrin deposition and stent occlusion was assessed after 1 Ph.D. thesis submitted to Anand Agricultural University, Anand Campus, Anand-388 001 unilateral nephrectomy at 30 and 90 days (6 dogs at each interval). There was no vascular occlusion in hind limbs of all stented vessels. Each stented vessel was subjected to resin embedding technique and MMA sections were obtained using tungsten carbide knife for Haematoxylin-Eosin (HE) staining. On histological examination, compared with control (SESs), arteries with HSESs showed marked reduction in peristrut fibrin deposition and non-occlusive thrombus formation [5 out of 6 (88.33%) with SRL versus 3 out of 6 (50.00%) with HS]. There was evidence of early complete re-endotheliazation with group HS compared to SRL. Enzymuria was seen in both groups with significant increase in group SRL at 48 hrs of post-stenting. Group HS had significant increase in serum Na+ concentration. However, blood and urine parameters revealed non-significant variations between HS and SRL groups. Serum Cr and protein had increased non-significantly more in HS group may be due to surgical procedural injury. Thus dual drug elution with Heparin-Sirolimus stent, coated with a biodegradable polymer reduces peristrut fibrin deposition and promotes early reendotheliazation in dog trans-femoral balloon injured renal polar artery model and its potential for reducing stent related thrombosis in humans warrants further clinical evaluation.