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Anand Agricultural University, Anand

Anand Agricultural University (AAU) was established in 2004 at Anand with the support of the Government of Gujarat, Act No.(Guj 5 of 2004) dated April 29, 2004. Caved out of the erstwhile Gujarat Agricultural University (GAU), the dream institution of Sardar Vallabhbhai Patel and Dr. K. M. Munshi, the AAU was set up to provide support to the farming community in three facets namely education, research and extension activities in Agriculture, Horticulture Engineering, product Processing and Home Science. At present there seven Colleges, seventeen Research Centers and six Extension Education Institute working in nine districts of Gujarat namely Ahmedabad, Anand, Dahod, Kheda, Panchmahal, Vadodara, Mahisagar, Botad and Chhotaudepur AAU's activities have expanded to span newer commodity sectors such as soil health card, bio-diesel, medicinal plants apart from the mandatory ones like rice, maize, tobacco, vegetable crops, fruit crops, forage crops, animal breeding, nutrition and dairy products etc. the core of AAU's operating philosophy however, continues to create the partnership between the rural people and committed academic as the basic for sustainable rural development. In pursuing its various programmes AAU's overall mission is to promote sustainable growth and economic independence in rural society. AAU aims to do this through education, research and extension education. Thus, AAU works towards the empowerment of the farmers.

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Subject: Veterinary Pharmacology × Author: PARSOTTAMDAS, GOHEL DARPESHKUMAR × End date: 2006 × Start date: 2006 × Type: Thesis × Thesis Type: M.V.Sc. ×
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    ThesisItemOpen Access
    STUDIES ON THE PHARMACOKINETICS OF MELOXICAM FOLLOWING INTRAVENOUS, INTRAMASCULAR AND ORAL ADMINISTRATION IN DOGS
    (AAU, Anand, 2006) PARSOTTAMDAS, GOHEL DARPESHKUMAR; SARVAIYA, J. G.
    Meloxicam is a new non-steroidal anti-inflammatory drug of oxicam family. It is having more selectivity towards cyclooxygenase-2 rather than cyclooxygenase-1. In the present study, pharmacokinetics and dosage regimen of meloxicam was determined in mongrel dogs following single dose intravenous, intramuscular and oral administrations of meloxicam (0.4 mg.kg-1 body weight). Following intravenous route, the disposition kinetics of meloxicam was best described by a two-compartment open model. The distribution and elimination half-lives of meloxicam were 0.262 ± 0.04 and 25.94 ± 0.65 h respectively. The values of zero time plasma drug concentration and area under curve of meloxicam were 1.608 ± 0.14 μg.h ml-1 and 35.56 ± 3.62 μg.h ml−1, respectively. The values of area under moment curve were 922.3 ± 81.33. The values of apparent volume of distribution, volume of distribution at steady state, volume of drug in central compartment and volume of drug in peripheral compartment were 0.395 ± 0.05, 0.313 ± 0.04, 0.262 ± 0.01 and 0.14 ± 0.04 L.kg−1, respectively. The first order rate constants from central compartment to peripheral and peripheral to central compartment were 0.853 and 2.08 h- 1, respectively. The values of total body clearance and mean residence time were 0.195 ± 0.02 ml.min−1.kg−1 and 26.13 ± 0.51 h, respectively. On the basis of values of pharmacokinetic variables obtained by intravenous administration of meloxicam (0.4 mg.kg−1 body weight), the optimal intravenous dosage regimens of meloxicam would be 0.33 mg.kg−1 as priming dose followed by 0.28 mg.kg−1 as maintenance dose to be repeated at 72 h interval. In present study, the Pharmacokinetic of meloxicam through intramuscular and oral route of administration were described by non-compartmental analysis in dogs. The elimination half-lives for i.m and oral route of administration was 23.41 ± 0.93 h and 21.18 + 1.22 h, respectively. The values of area under curve were 33.40 ± 2.02 μg.h.ml-1 and 32.62 + 2.14 μg.h.ml-1 for i.m and oral route of administration, respectively. The value of area under first moment of curve were found to be 1259 ± 35.1 μg.h2.ml-1 and 1607.29 + 185 μg.h2.ml-1. The values of MRT were 38.38 ± 2.46 and 48.72 + 3.63 h, respectively. Values of F for i.m. and oral study were 0.96 ± 0.06 and 0.95± 0.07 % respectively. On the basis of observed meloxicam concentration in plasma, the drug can be given intramuscularly or orally at dose rate of 0.4 mg/kg to be repeated at an interval of 48 h.