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1978 - 19792
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Subject: Veterinary Pharmacology and Toxicology × Author: KAU × End date: 1979 × Start date: 1977 × Thesis Type: M.V.Sc. ×
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    ThesisItemOpen Access
    Assessment of the antifertility property of ocimum sanctum
    (Department of Pharmacology and Toxicology, College of Veterinary and Animal Sciences, Mannuthy, 1979) Girisdan, K; KAU; Jacob Cheeran, V
    A study was carried out in rats, to assess the antifertility property of the benzene fraction of the leaves of the plant Ocimum sanctum. Premating treatment was done in female animals at does levels of 200 and 400 mg per kilogram body weight for a duration of eight days. Male animals were subjected to the treatment at a dose level of 200 mg per kilogram body weight for 20 days . The experimental animals were allowed to mate with untreated animals of the opposite sex. Histopathological examination of the organs – pituitary, ovary, tests, liver and kidney were carried out. Results of the study suggested considerable reduction of fertility in both the sexes. This can be attributed to the impaired release of gonadotrophic hormones and the resulting improper functioning of the gonads. Administration of the extract showed no toxic effects in the treated rats as well as in their offspring.
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    Studies on the influence of chloramphenicol on thiopentone sodium anaesthesia in dogs
    (Department of Pharmacology and Toxicology, College of Veterinary and Animal Sciences, Mannuthy, 1978) Aravindakshan, C M; KAU; Zacharias, Cherian
    A study was undertaken to find out the influence of chloramphenicol, streptomycin and kanamycin on thiopentone sodium anaesthesia in dogs. Chloramphenicaol 50 mg/kg body weight, streptomycin 10 mg/kg body weight and kanamycin 10 mg/kg body weight were administered intramuscularly at 30, 60 and 120 minutes prior to the administration of thiopentone sodium, which was given at the rate of 30 mg/kg body weight intravenously. These antibiotics (chloramphenicol, streptomycin and kanamycin) produced a slight prolongation in the surgical anaesthesia and sleeping time, induced by thiopentone sodium. Chloramphenicol showed a significant effect over the other two drugs in these respects. It was also noticed that neither thiopentone sodium nor its administration along with chloramphenicol, streptomycin and kanamycin does possess any influence on the PCV and ESR values.