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ThesisItem Open Access Prevalence clinical pathology and treatment of microfilariasis in dogs in Thrissur(Department of Parasitology, College of Veterinary and Animal Sciences, Mannuthy, 1997) Radhika, R; Radhika, R; KAU; KAU; Subramanian, H; Subramanian, HIn a detailed study conducted on prevalence, clinical pathology and treatment of microfilariasis in dogs in Thrissur, it has been found that canine microfilariasis is prevalent throughout the year with more incidence during \ summer. The most reliable and accurate diagnostic method for detecting microfilariae, was noted to be the Modified Knott's Technique while wet film examination was more useful for preliminary screening. Microfilariae encountered were identified as those of Dirofilaria repens. The affected dogs revealed haematological changes like increase in ESR, TLC, eosinophils as well as lymphocytes and decrease in Hb, TEC, PCV as also neutrophils. Biochemical studies revealed increase in Serum Total Protein, Globulin, AST, ALT, BUN as well as Serum Urea in microfilaraemic dogs and higher levels of Albumin, Albumin/Globulin ratio in non-microfilaraemic dogs. Single oral dose of Milbemycin oxime at 0.5 mg/kg b.w. was found to be the most effective drug for microfilariasis, followed by single s/c dose of Ivermectin at 200 mg/kg b.w. and 7 consecutive daily s/c dose of levamisole at 7.5 mg/kg.