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20122
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Subject: Veterinary Surgery × End date: 2013 × Start date: 2012 × Type: Thesis ×
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    ThesisItemOpen Access
    STUDIES ON DIAGNOSTIC IMAGING OF THORACIC CAVITY IN DOGS WITH SPECIAL REFRENCE TO RESPIRATORY SYSTEM
    (Sri Venkateswara Veterinary University, TIRUPATI – 517 502,A.P, 2012-10) REETU; SURESH KUMAR, R.V (Major); VEENA, P; SRILATHA, Ch
    ABSTRACT : The present study was carried out for the diagnosis of thoracic diseases specially related to respiratory system with the use of imaging techniques. Out of 597 dogs presented to the college clinics 223 (37.35 %) dogs were found with some thoracic affection among which 106 (17.76%) cases were found to have respiratory involvement. Incidence of respiratory affections were found highest in aged dogs 52 (49.1%) followed by adults 42 (39.6%) and young dogs 12 (11.3%). It was found that males were more affected compared to females. Incidence among breed showed a statistics of highest in Mongrel dogs 42 (39.6%) followed by Pomeranian 28 (26.4%), German shepherd 12 (11.3%), Labrador retriever 10 (9.4%), Boxer 5 (4.7%), Great dane 4 (3.77%), Dalmatian 3 (2.83%) and least in Pug i.e. 2(1.89%). Out of these 106 cases of respiratory ailments 31 (29.25%) dogs had pneumonia, 20 (18.87 %) animals were diagnosed with tracheobronchitis, 18 (16.98 %) had metastatic masses, 14 (13.21%) dogs diagnosed with pulmonary oedema, 9 (8.49%) had pleural effusion, 7 (6.6%) dogs diagnosed with pneumothorax, 5 (4.72 %) dogs had diaphragmatic hernia, and 2 (1.89 %) were diagnosed with tracheal narrowing. On the basis of clinical signs cases were subjected to further diagnosis for the study. Radiography was used as the first technique to screen out respiratory ailments from the cardiac affections. It was useful in diagnosis of pneumonia, metastatic lesion, diaphragmatic hernia and pleural effusion. Thoracic ultrasound was used further to confirm the radiological diagnosis and conditions like pneumonia, diaphragmatic hernia and pleural effusion etc. Tracheobronchoscopy was also used additionally for confirmatory diagnosis of diseases like tracheitis and bronchitis which were difficult to diagnose through radiograph or ultrasound procedures. Various blood parameters were evaluated; a marked neutrophilia, leukocytosis and lymphopenia were seen along with moderate monocytosis. There was no significant change observed in haemoglobin and total erythrocyte count but packed cell volumes were found elevated in diseased dogs. Total protein levels were also found significantly low in affected dogs and a mild hypoalbuminaemia were also seen. Bronchoalveolar lavage was also performed during tracheobronchoscopy and cytological interpretation was done for the fluid which showed increased number of neutrophils and degenaerated neutrophils in the samples. Antibiotic sensitivity test was also done with these samples and results were obtained against enrofloxacin with highest sensitivity followed by ciprofloxacin and least for cephalosporin. Diagnosed cases were effectively treated with a combination of antibiotics, antihistaminics, corticosteroids, antipyretics and supportive therapy. Surgery was performed some cases where required.
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    ThesisItemOpen Access
    EVALUATION OF CHITOSAN-POVIDONE IODINE COMPOSITE FILMS ON CUTANEOUS WOUND HEALING IN RABBITS
    (Sri Venkateswara Veterinary University, TIRUPATI – 517 502,A.P, 2012-10) SUMIRAN, N; VEENA, P (Major); SURESH KUMAR, R.V; SRILATHA, Ch
    ABSTRACT: Eighteen rabbits were divided into three groups of six each to study the efficacy of chitosan and chitosan-povidone iodine composite films on cutaneous wounds of 1x1 cm area. The wounds in all the groups were protected with external bandaging after thorough cleaning with normal saline to prevent infection. Chitosan films were applied in group II and chitosan – povidone iodine composite films in group III . The efficacy of these biocasings were studied based on gross, physiological, haematological, biochemical and histopathological changes at different periods of observations. Wounds were evaluated clinically by observing the appearance, extent of cicatrisation and percentage of wound contraction in all the groups of animals at different time intervals. Early wound healing was observed in group II (15.33±0.21 days) as compared to group I (18.5±0.22) and group III (16.5±0.22). None of the animals showed host rejection or local tissue reaction. Accumlation of wound fluid was more in group I as compared to other two groups. The biocasings were clearly adhered to the wound surface and prevented haemorrhage. Physiological parameters like temperature, respiration and pulse rates did not show any significant changes during the period of observations and were within the physiological range. Total erythrocyte count, total leucocyte count, haemoglobin, PCV, neutrophil count, and lymphocyte count showed significant differences. However monocyte count, eosinophil count and basophil count didnot show any significant changes. The wound healing was evaluated microscopically and by biochemical estimation of hydroxyproline , hexosamine and trace elements like zinc, iron, copper in biopsy specimens collected from wound at 7th, 14th day after treatment. The values of hydroxyproline and all the elements were lower in the initial stages of wound healing, whereas hexosamine values decreased with the progression of healing. None of the animals in all the groups showed CRP positive reaction. Histopathologically, early epithelialisation and marked fibrovascular proliferation were noticed in chitosan treated animals when compared to other groups. . However metaplastic changes and gaint cells were not noticed, suggesting safety of biocasings. Based on the above findings, it was concluded that use of chitosan film for cutaneous wound healing in rabbits was effective without any adverse effects.