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Authors: Kumaraguruparan, R.
Subapriya, R.
Balachandran, C.
Manohar, B. Murali
Thangadurai, A.
Nagini, S.
Title: Xenobiotic-Metabolizing Enzymes in Canine Mammary Tumours
Publisher: The Veterinary Journal
Language: en
Type: Article
Agrotags: Canine Mammary Tumour
Cytochrome P450
y-Glutamy1 Transpeptidase
Glutathione S-Transferase
Abstract: Mammary tumours are the most common neoplasms in female dogs. The present study was designed to evaluate the relationship between different clinical stages with activities of phase I and phase II carcinogen-metabolizing enzymes in canine mammary tumours. The levels of cytochrome P450 and cytochrome b5 and the activities of glutathione S-transferase (GST), y-glutamy1 transpeptidase (GGT), DT-diaphorase (DTD) and NADPH diaphorase in tumour tissues of 25 bitches was estimated. Enhanced levels of cytochrome P450 and b5 and phase II enzyme activities were observed in tumour tissues compared to the corresponding uninvolved adjacent tissues. The magnitude of the changes in phase I and phase II enzyme status was, however, more pronounced in stages I and II compared to stages III and IV. The results suggest that the balance between phase I carcinogen activation and phase II detox © 2005 Elsevier Ltd. All rights reserved.
Issue Date: 2006
Appears in Collections:Articles (1.Journal)

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