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Authors: Sumathi, D
Advisor: Prathaban, S
Title: Study On The Comparative Efficacy Of Diagnostic Tests In The Early Diagnosis Of Canine Liver Diseases
Publisher: Tamil Nadu Veterinary and Animal Sciences University
Language: en
Type: Thesis
Agrotags: Canines
liver diseases
Abstract: The early diagnosis of liver disease remains a major challenge for the veterinary practitioners. In this back drop, a study entitled “Study on the comparative efficacy of diagnostic tests in the early diagnosis of canine liver diseases” was planned and conducted with the objectives of evaluating the incidence, etiological pattern, clinico-pathological and ultrasonographic changes of canine liver diseases. The study consisted of 6 healthy dogs acting as controls and 100 cases of various liver diseases, which were divided into three groups viz. parenchymal disorders, biliary disorders and neoplastic disorders. The parameters studied consisted of incidence analysis, medical history, clinical and physical examination findings, hemato-biochemical parameters (Hemoglobin, Total erythrocyte count, PCV, MCV, MCH, MCHC, Total leucocyte count, Differential count, Cholesterol, ALP, ALT, AST, GGT,BUN, Creatinine, Glucose, Total protein, Albumin, Total Bilirubin, Direct bilirubin), Coagulation parameters (Platelet, PT and aPTT), Ultrasonography, cytology and histopathological findings . The incidence of canine liver diseases was 0.15 per cent of total number of medical cases attended and 0.43 per cent of the gastrointestinal case loads of the Madras Veterinary College Teaching Hospital. The mostcommon liver disease was that of parenchymal disorders with 73 percent incidence (73/100), followed by biliary disorders 18 per cent (18/100) and neoplastic disorder 9 per cent (9/100). Non-descript dogs dominated the incidence in all the groups of liver diseases followed by Spitz in both neoplastic disorders and parenchymal disorders.In case of biliary disorders German shepherd followed the Non descript dogs in the incidence levels. Dogs aged above four years were most commonly affected and males dominated the incidence in all groups of liver diseases. Common clinical signs observed in biliary disorders were vomiting followed by anorexia / decreased appetite and weight loss, jaundice and abdominal pain. The commonly observed clinical signs in neoplastic disorders were weakness and anaemia (Tachycardia/Tachypnoea) followed by anorexia / reduced appetite, palpably distended liver (Hepatomegaly), poor hair coat, vomiting, weight loss and ascites. The commonly observed clinical signs in parenchymal disorders were anorexia / reduced appetite followed by weight loss, vomiting, palpably distended liver (hepatomegaly), ascites, diarrhoea and abdominal pain. Clinico-pathological changes such as erythrogram revealed a significant anaemia in all the three groups. Leucocytosis with neutrophilia was observed in all the three groups. Similarly a significant reduction in total protein and allbumin levels was found to be consistent in all the three groups. The total bilirubin and direct bilirubin was significantly elevated in biliary disorders group.Though the elevation in liver enzyme activities was evident they were statistically non significant. Due to these limitations, ultrasound imaging was deployed and the same was found to have better diagnostic yield. Histopathology formed the gold standard in classification of type of liver dieases. 3D ultrasonography studies helped in better visualisation of lesions in liver diseases.
Subject: Clinical Medicine and Therapeutics
These Type: Ph.D
Issue Date: 2012
Appears in Collections:Theses & Dissertations

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