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Authors: Kavitha, S
Advisor: Nambi, A.P.
Srinivasan, S.R.
Manohar, B. Murali
Jayaprakash, R
Title: Evaluation Of Effects Of Ace Inhibitors In The Control Of Progression Of Chronic Renal Disease In Dogs
Publisher: Tamil Nadu Veterinary and Animal Sciences University
Language: en
Type: Thesis
Abstract: The aim of the study was to evaluate the effect of ACE inhibitors in the control of progression of chronic renal disease in dogs. Ten apparently healthy dogs from Tamilnadu Commando School, dog squad were selected as control animals for comparison of various parameters under study. In the clinical study dogs with clinical signs suggestive of chronic renal disease were subjected to detailed physical examination, blood pressure measurement, hematology, serum biochemistry, urinalysis, nephrosonography, radiography and electrocardiography. Based on these parameters one hundred and two dogs were identified as having chronic renal disease and were classified into 4 stages as stage-I, stage-II, stage III and stage IV according to IRIS staging system for chronic renal diseases. Dogs from stage I to stage III were randomly subjected to treatment trial with enalapril @ 0.5 mg/kg b.wt and benazepril @ 0.5 mg /kg b.wt p/o separately over a period of 6 months.The parameters studied were history, clinical signs, blood pressure measurement, urinalysis, haemogram, leukogram, nephrosonography, radiography, electrocardiography and ophthlamoscopy. In the treatment group clinical signs, blood pressure, hematobiochemical examination and urinalysis were studied during the course of treatment (i.e) 1 st month, 3 rd month and 6 th month of treatment. The predominant clinical signs observed in stage I and II were polyuria, polydipsia, and anorexia. In stage III and IV gastrointestinal signs such as anorexia, vomiting, diarrhoea, stomatitis, melena, and other manifestations such as emaciation, pale mucous membrane and uremic encephalopathic signs were observed. Normal arterial blood pressure was recorded from stage I to stage III degree and systemic hypertension was recorded in stage IV CRD dogs. Urinalysis revealed isosthenuria and mild to moderate proteinuria in all the dogs with CRD. Anemia was characteristic in all stages of CRD. Leukocytic neutrophilia was observed in stage IV CRD dogs. Nephrosonography revealed hyperechoic cortex, indistinct cortico medullary junction and altered renal architecture. Ophthalmoscopic examination showed hypertensive retinal changes such as tortuous vessels, retinal hemorrhage in five dogs with stage IV CRD. Hyperkalemic changes in electrocardiography was observed in stage IV dogs. Postmortem examination was performed in dogs that died from stage IV CRD. In the treatment trial, improvement in appetite, body weight, coat condition, general behaviour was observed. No hematobiochemical changes were observed during course of treatment. Reduction in proteinuria was observed in both the treatment groups in all the stages. Marginal decrease in systemic arterial blood pressure, serum creatinine and SUN was observed in both treatment groups. The response to treatment based on serum creatinine, SUN, blood pressure and urinary protein, revealed no progression to severity of disease in stage- I and II and reduction of serum creatinine (improvement) in stage III CRD in dogs.
Subject: Veterinary Clinical Medicine
These Type: Ph.D
Issue Date: 2008
Appears in Collections:Theses & Dissertations

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