Please use this identifier to cite or link to this item: http://krishikosh.egranth.ac.in/handle/1/5810133637
Authors: Srivastava, Radhika
Advisor: Sushma, Dr. (Mrs.)
Title: In vivo assessment of immunomodulatory and hepatoprotective potentials of Tinospora cordifolia in mice
Publisher: Department of Biochemistry and Biochemical Engineering Jacob Institute of Biotechnology and Bioengineering Sam Higginbottom University of Agriculture, Technology and Sciences, Allahabad-211007, India
Language: en
Type: Thesis
Pages: 132p.
Agrotags: null
Keywords: Keywords: Hematology, Mice, Tinospora cordifolia, Immunomodulation, Carbon tetrachloride, TC Extracts, Hepatoprotective activity, Phytochemical
Abstract: The present study was carried out to of immunomodulatory and hepatoprotective potentials of aqueous extract Tinospora cordifolia. In the immunomodulatory and hepatoprotective potentials studies and immunomodulatory studies were conducted in mice which were divided into seven groups. The different groups in this study included group I control, group II reference control (silymarin 25 mg/kg. The mice were administered carbon tetrachloride orally at doses of 200 and 400 mg/kg mice body. Finally 200 mg/kg b.w. was taken as the therapeutic oral dose for aqueous extracts. The animals were examined daily for any clinical symptoms, blood samples were collected at different intervals like 7th, 14th, and 21st-day post induction of toxicity and levels of neutrophilic adhesion, DTH, serum Immunoglobin, cell-mediated immune response and HA titre measured.The results confirm the tough effect of carbon tetrachloride on the liver cause while enzymes consisting of SGOT, SGPT had been found eminent in the serum. In conclusion with these results, it can be said that the leaf extracts of T. cordifolia exhibited a hepatoprotective effect against carbon tetrachlorideinduced hepatotoxicity.
Description: Ph.D. Thesis
Subject: Biochemistry
Theme: In vivo assessment of immunomodulatory and hepatoprotective potentials of Tinospora cordifolia in mice
Research Problem: In vivo assessment of immunomodulatory and hepatoprotective potentials of Tinospora cordifolia in mice
These Type: Ph.D
Issue Date: 2019
Appears in Collections:Thesis

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