Please use this identifier to cite or link to this item: http://krishikosh.egranth.ac.in/handle/1/5810114673
Authors: Sheetal
Advisor: Rajvir Singh
Title: Design, synthesis and bioevaluation of some novel bioactive ingredients
Publisher: CCSHAU
Language: en
Type: Thesis
Agrotags: null
Keywords: Coumarins, Chalcones, Propranolols, Proterenols, Pyrazoles, Antifungal, Antibacterial, Herbicidal activity
Abstract: Coumarins, Chalcones, Propranolols, Proterenols, and Pyrazoles are versatile classes of heterocycles and intermedients for the preparation of other organic compounds due to their various biological activities. Many natural and synthetic drugs, dyes, pesticides are heterocyclic in nature. These compounds were synthesized by conventional method. These compounds were characterized by spectroscopic technique viz. 1NMR, IR, Elemental analysis and other analytical data. Synthesized compounds were screened for their Fungi toxicity by poison food technique at four different concentrations. Compounds 13 and 25 were found more active against the tested fungi Rhizoctoniasolani and Aspergillusniger which haveEC50values 52.91, 71.88 and 48.00, 78.60μg/ml respectively. Compounds 34 and 105were found more active against the tested fungi Rhizoctonia solani and Aspergillus niger which have EC50 values 40.51, 60.49 and 57.25, 56.52μg/ml respectively. Synthesized compounds were screened for their antibacterial activity by zone inhibition method at four different concentrations. Compounds 17 and 27 were found more active against Bacillus species at all the test concentrations. Compounds 79 and 132 were found more toxic against the Bacillus species at all the test concentrations. Compound 179 was found more toxic against the Bacillus species at all the test concentrations. Synthesized compounds were also screened for their herbicidal activity against growth of weed roots and shoots of Raphanussativus L. in vitro by percentage inhibition technique. Compounds 13 and 67 were found more toxic in % growth inhibition of both roots and shoots at all the tested concentrations. Compounds 92 and 118 were found more toxic in % growth inhibition of both roots and shoots at all the tested concentrations. Compounds 132 and 153 were found more toxic in % growth inhibition of both roots and shoots at all the tested concentrations.
Subject: Chemistry
Theme: Design, synthesis and bioevaluation of some novel bioactive ingredients
These Type: Ph.D
Issue Date: 2019
Appears in Collections:Theses

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