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|Advisor:||Dr. P. NAGARAJ|
|Title:||CLINICO-HAEMATOBIOCHEMICAL AND THERAPEUTIC STUDIES ON COLIBACILLOSIS IN DIARRHOEIC GOAT KIDS|
|Abstract:||An investigation was undertaken to study the prevalence, clinical features certain haematobiochemical changes and to suggest suitable therapeutic regimen for colibacillosis in diarrhoeic goat kids. Diarrhoeic goat kids that presented to Veterinary Clinical Complex, College of Veterinary Science, Rajendranagar, Hyderabad during the period of nine months i.e., from December, 2017 to August, 2018 were examined for colibacillosis. Out of 72 diarrhoeic goat kids examined, 27.78% (20/72) kids were found affected with colibacillosis viz. E. Coli on faecal cultural studies. In the present study, the cases were categorized into 0 to 15 days, 15 to 30 days, 30 to 45 days and 45 to 60 days age groups. An age wise prevalence of 38.89% (7/18) in 45 to 60 days age groups, 30% (6/20) in 0 to 15 days, 22.22% (4/18) in 15 to 30 days and 18.75% (3/16) in 30 to 45 days age groups were recorded. The disease was found prevailing in 42.10% (16/38), non-descript diarrhoeic kids and 22.22% (4/18) in Jamunapari kids. In the present studies, the colibacillosis was found in 28.57% (8/28) in female diarrhoeic kids and 27.27% (12/44) in male kids. During the study, ten healthy goat kids free from endoparasitic ova and colibacillosis (E. Coli) were selected and kept as Healthy control (Group-I) (n=10). The twenty colibacillosis affected diarrhoeic kids were randomly divided into two groups viz. Group II (n=10) and Group III (n=10) and studied further. The clinical features recorded in cases of Group II (n=10) were 60% (6/10) fed on dam’s milk, 40% on bottle milk, 70% (7/10) showed inappetence, 20% (2/10) had rough hair coat, 40% showed pale and congested mucous membranes, 40% recorded 2 seconds and 30% recorded 3 and 4 seconds skin tenting time, respectively and 50% showed formed with fluid, 30% showed fluid with some solid and 20% showed watery without solid faeces. The clinical features recorded in cases of Group III were 70% fed on dams milk, 30% on bottle milk, 80% showed inappetence, 30% had rough hair coat, 40% showed pale and congested mucous membranes, 40% recorded 2 seconds and 30% recorded 3 and 4 seconds skin tenting time, respectively and 40% showed formed with fluid, and 30% showed fluid with some solids and 30% showed watery without solid faeces. In colibacillosis effected kids in Group II and Group III, the increase in rectal temperature, pulse rate, respiratory rate [Group II (P<0.05)] and heart rate were found significant (P<0.01). The faecal cultural examination of diarrhoeic goat kids on selective and differential media namely EMB and MacConkey agar media revealed E. coli organisms. The pure cultures of E. coil were confirmed on biochemical tests viz, IMViC reactions. The Grams staining revealed Gram negative medium sized rods of E. Coli. In vitro drug sensitivity showed 90% (18/20) were sensitive to amoxicillin + clavulunic acid, 85% (17/20) to gentamicin, 65% (13/20) to ceftriaxone, 50% (10/20) to ampicillin, enrofloxacin and cefaperazone drugs. However, the colibacillosis affected kids were resistant to cloxacillin and methicillin. The haematological evalution on Hb, PCV, TEC, TLC and DLC in the colibacillosis affected kids. In Group II and III revealed a significant ( P<0.01) increase in PCV, TLC, neutrophils counts and decrease in Hb, TEC and lymphocytic counts indicating haemoconentration, leucocytosis, neutrophilia, anaemia and lymphopenia. The biochemical evaluation on BG, TP, albumin, globulin and ALT in the colibacillosis effected kids in Group II and III revealed a significant (P<0.01) increase in the level of ALT and decrease in BG, TP, albumin and globulin indicating hypoglycaemia, hypoprotinaemia, hypoalbuminaemia and hypoglobulinemia in the affected kids. All the cases of colibacillosis in Group II were treated with injection Gentamicin and Group III with injection Amoxiclav. A common supportive therapatic regimen consisting of Inj. RL, Inj. meloxicam, Inj. Bcomplex (B1+B6+B12) were administered in the affected kids of both the groups. All the cases in Group II and III showed clinical recovery on completion of course of treatment (5 days). Both the therapatic regimens were found 100% effective in the treatment of colibacillosis in the dirarhoeic goat kids. On comparison the treatment efficacy between the drug regimens of the Groups II and III was found ‘equally’ good. However, based on the results of haematobiochemical studies in both the groups it was recommended to continue additional treatment with haematinics and protein energy supplementation in the effected kids.|
|Appears in Collections:||Thesis|
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