Please use this identifier to cite or link to this item: http://krishikosh.egranth.ac.in/handle/1/5810085989
Authors: Rath, Madhuparn
Advisor: Pradhan, Sukanta Kumar
Title: COMPUTER AIDED DRUG DESIGNiNG: MOLECULAR DOCKING OF ACETYLCHOLINESTERASE INHIBITORS ON SELECTED DRUG TARGETS OF AD TO REVEAL NEW INSIGHTS IN ITS TREATMENT
Publisher: Orissa Univesrity of Agriculture and Technology; Bhubaneswar
Language: en
Type: Thesis
Pages: 31
Agrotags: null
Keywords: Computer, Aided, Drug , Designing:, Molecular, Docking , Acetylcholinestarage, Inhibitors , Selected, Drug, targets of , Reveal, Insights, Treatment.
Abstract: "Alzheimer's disease is the most common fonn of dementia among elderly people characterised by progressive and degenerative disorrler of brain. An imp0l1ant characteristic of AD is the deposition of amyloid fibrils and neurofibrillary tangles in the brain of affected individuals mainly composed of f3-amyloid protein and phosphorylated tauproteins respectively. There is also a loss of the presynaptic markers of the cholinergic system, such as acetylcholine. The important genes now targeted for treatment of early onset of AD arc pAmyloid Protein Precursor (APP), Apolipoprotein E (APOE) and Presenilin I (PS I). In our in silica study facilitated by molecular docking studies of four acetylcholinesterase inhibitors Tacrine, Donepezil, Rivastigmine and Galantamine on these three proteins revealed some important H-bond interaction with residues located in the active site pockets. This residue infonnation can be used for further high throughput screening of large scale ligands, QSAR (2d and 3D), pharmacophore modeling and structure based drug designing."
Description: TH-3870
Subject: Bioinformatics
Theme: COMPUTER AIDED DRUG DESIGNiNG: MOLECULAR DOCKING
These Type: M.Sc
Issue Date: 2012
Appears in Collections:Thesis

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