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Authors: Punia, Manisha
Advisor: Ashok Kumar
Title: Haemato-biochemical and therapeutic studies in dogs afflicted with urinary tract infection
Publisher: LUVAS
Language: en
Type: Thesis
Agrotags: null
Keywords: Dog, antibiotic sensitivity, amoxicillin-clavulanic acid, ceftriaxone-tazobactam, haematobiochemical.
Abstract: Urinary tract infection (UTI) refers to the microbial colonization of the urinary tract or any urinary tract organ, except the distal urethra, which has a normal bacterial flora. Twenty two cases were included in the study on the basis of history, clinical signs, urinalysis and haemato-biochemical findings. Major clinical signs observed in dogs affected with UTI were inappetence, fever, weakness in the hind limbs, stranguria, urine incontinence, halitosis, hematuria, oliguria, vomiting and hypersalivation. Highest prevalence of UTI was found in Pug (36.36%) followed by Labrador retriever (22.72%) and German shepherd (13.63%) breeds with more prevalence in males (95.4%) than females (4.6%). Prevalence of UTI was highest (40.9%) in lower age group i.e. below 4 yrs of age. The affected dogs showed decreased values of Hb, TEC and PCV with leucocytosis. The serum biochemical parameters exhibited an increase in blood urea, creatinine, phosphorous, protein, albumin, potassium and decrease in sodium and calcium values whereas values of chloride, globulin, glucose, SGOT and SGPT were within the reference range. Examination of urine revealed haematuria, proteinuria, bilirubinuria, pyuria, cylindiuria and crystalluria. On culture examination, most common bacterial isolates obtained from urine were E. coli and Streptococcus spp. followed by Staphylococcus spp., Klebsiella spp. and Bacillus spp., respectively. Overall maximum sensitivity of 27 isolates was found towards ceftriaxone/tazobactam (88.88%) followed by ceftriaxone (77.77%), chloramphenicol (74.07%), gentamicin and cefoperazone (70.3%), amoxicillin/clavulanic acid and neomycin (55.55%), amikacin (48.14%), streptomycin (44.44%), ampicillin (40.74%), enrofloxacin (37.03%), oxytetracycline and penicillin-G (33.33%), amoxicillin and cloxacillin (29.62%), respectively. On the phenotypic in vitro sensitivity pattern, we found 24 isolates to be multidrug resistant and among them, two isolates were extreme drug resistant and one was pan drug resistant isolate. In the present study, UTI affected dogs were divided into two groups A and B containing six dogs each. Group-A was treated with ceftriaxone-tazobactam combination @20 mg per kg BW once daily by IM route for 5 days and group-B with amoxicillin-clavulanic acid combination @20 mg per kg BW twice daily by oral route for 7 days. The percent efficacy of treatment has been recorded on the basis of remission of clinical signs and near normalisation of the renal function values. Thus, it was seen that percent efficacy of group A was 100% while it remained 83.3% in group B as one case was presented again in clinics with signs of UTI in group B.
Subject: Veterinary Medicine
Theme: Haemato-biochemical and therapeutic studies in dogs afflicted with urinary tract infection
These Type: M.V.Sc.
Issue Date: 2018
Appears in Collections:Thesis

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