Please use this identifier to cite or link to this item: http://krishikosh.egranth.ac.in/handle/1/5810040165
Authors: Pratheepa, K.
Balachandran, C.
Vijaya, K.
TANUVAS
Title: Assessment of the Immune Status in “Withaferin A” Treated Rats in Experimental Mammary Carcinogenesis by Flow Cytometry
Other Titles: Indian Veterinary Journal
Publisher: TANUVAS
Language: en
Type: Article
Pages: 33-35
Volume: 95
Series/Report no.: ;01
Agrotags: Veterinary Science
Keywords: CD3 T lymphocytes, DMBA, Mammary carcinogenesis, Withaferin A
Abstract: The present study was carried out to evaluate the immunomodulatory effect of Withaferin A in DMBA (7,12-dimethylbenz[a]anthracene) induced mammary carcinogenesis in rats. Twenty four female Sprague-Dawley (SD) rats were equally distributed to control, DMBA, DMBA+Tamoxifen (Standard drug) and DMBA+Withaferin A groups. Peripheral blood was collected at the 120th day from the initial dose of DMBA and CD3, total T lymphocytes were determined by using  ow cytometry. There was signi cant (P<0.05) increase in the total T lymphocytes (CD3) in the DMBA+Withaferin A group from DMBA+Tamoxifen group indicating immunostimulatory effect of Withaferin A.
Description: TNV_IVJ_Jan2018_V95_I01_33-35
Issue Date: 2018-01
Appears in Collections:Articles (1.Journal)

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