Studies on diagnosis and management of oral tumors in bovines
Bisla, Ranbir Singh
2019
Ph.D
The present study was undertaken in 29 cattle and buffaloes affected with tumourous growth in oral cavity to diagnose the types of oral tumours using histopathology and immunohistochemistry and to compare the efficacy of chemotherapy in comparison to surgical intervention followed by chemotherapy. The animals were randomly divided into three groups; eight animals in groups I and II each and thirteen animals in group III. In group I, vincristine sulphate was given @ 0.75 mg/m2 intravenously at weekly interval for 4-6 times and in group II, vincristine sulphate (as in group I) along with anthiomaline (15-20 ml deep intramuscular injection on alternate days for six times) was administered. In group III, tumourous growths were excised followed by chemotherapy as in group II. Radiography was helpful to diagnose the invasiveness of oral tumours, osteolytic changes, calcification, teeth displacement or any other changes to undertake the surgery accordingly. Radiographic examination revealed tooth displacement, osteolytic changes and calcification in 54%, 46% and 35% of animals affected with oral tumours respectively. Oral tumours in bovine were more common at mandibular region rather than maxillae and rostral mandible was the most affected site. Most of the oral tumours were hard in consistency, whitish pink in colour and size varied from 1 cm to 20 cm. On histopathological examination, all oral tumours were benign in nature. Fibroma, ameloblastoma and myxoma were the most common types of oral tumours; however, tumours of mixed origins were also observed. Immunohistochemical examination by p53 and CK 14 antibody in all the tumourous growth revealed none of the oral tumours were positive immunoreactivity for p53. It indicated that p53 is not important in pathogenesis of bovine oral tumours. Immunopositive reaction for CK14 was observed in ameloblastoma, papilloma and adenoma (epithelial tumours); however, no immunoreactivity was noticed in fibroma, myxoma and chondroma (mesenchymal tumours). In group I, only 25% and in group II only 38% of animals recovered which had small sized tumourous growths of fibroma origin. Vincristine sulphate was effective for the treatment of small sized bovine oral tumours; however, vincristine sulphate along with anthiomaline was better than vincristine sulphate alone. In group III, 70% animals recovered which showed surgical excision was required for large sizes bovine oral tumours along with chemotherapy for better results.
en
LUVAS
Veterinary Surgery and Radiology
Studies on diagnosis and management of oral tumors in bovines
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LUVAS-375382-Sandeep Kumar.pdf